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Abstract #0412

Pharmacokinetic analysis of DCE-MRI in pituitary adenoma: evaluation of tumor consistency and comparison with histological collagen content

Kiyohisa Kamimura1, Masanori Nakajo1, Tomohide Yoneyama1, Manisha Bohara1, Yoshihiko Fukukura1, Shingo Fujio2, Takashi Iwanaga3, Hiroshi Imai4, Marcel Dominik Nickel5, and Takashi Yoshiura1
1Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, 2Neurosurgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, 3Clinical Engineering Department Radiation Sectio, Kagoshima University Hospital, Kagoshima, Japan, 4Siemens Healthcare K.K., Tokyo, Japan, 5Siemens Healthcare, Erlangen, Germany

Preoperative information of tumor consistency is important in patients with pituitary adenoma. Our aim was to evaluate the possible role of high-temporal and spatial resolution dynamic contrast enhanced MR imaging (DCE-MRI) and quantitative pharmacokinetic analysis in differentiation of a hard adenoma from soft adenoma. The hard adenoma showed significantly higher extravascular extracellular space per unit volume of tissue (ve) than soft adenoma and the ve was significantly correlated to collagen IV content of pituitary adenomas. This quantitative pharmacokinetic parameter ve may be useful for differentiation of the hard adenoma from soft adenoma.

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