This study sought to provide a biological basis of radiomics-based analyses by assessing the relationship between MR features and analogous histomic features of the underlying tissue using coregistered histology samples taken at autopsy from brain cancer patients. Several radiomic features demonstrated substantial mutual information with their histomic analogs, with first order features showing the strongest associations. These histomic-preserving features were shown to be stable across potential confounds such as differences in scanner vender and acquisition field strength. These findings suggest that MR radiomic features reflect information about the texture of the underlying tissue.
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