Standard post-operative radiation therapy in glioblastoma delivers radiation uniformly across the hyper-intense areas from pre-operative FLAIR images and does not account for the regions where the infiltration might relapse. This work creates a non-invasive prognostic signature of the extent of recurrent hyper-intense FLAIR using radiomics features extracted from multi-modal MRI. Results demonstrate that the area of recurrence can be accurately predicted earlier with some radiomic features as beacon of recurrence than others when tested temporally across multiple time-points.
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