A new sequence design was used to combine the CEST saturation method with traditional MRS. Using non-water suppressed metabolite-cycled spectroscopy offers the time-saving simultaneous recording of the traditional CEST z-spectrum and the metabolite spectrum under frequency selective saturation and allows the detection of exchange and magnetization transfer effects on metabolites and macromolecules. This technique might offer additional possibilities for quantifying the metabolite and macromolecular content or give further insight into the composition of the traditional CEST z-spectrum and is also relevant for judging the influence of water-suppression on absolute metabolite signals.
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