Myelin accelerates neural signaling in the central and peripheral nervous systems. Ultrashort echo time (UTE)-based imaging techniques have been proposed for direct capture of magnetic resonance (MR) signal from myelin lipid protons with extremely short T2* (~0.3 ms). To suppress signal from long T2 water components and thereby improve myelin imaging, inversion recovery (IR)-based UTE techniques have been proposed. In this study, we explored the efficacy and feasibility of qualitative myelin imaging in vivo combining dual-echo IR-UTE with complex echo subtraction.
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