Concentration of contrast agent (CM), relaxivity (r1), extracellular pH (pHe), and oxygen extraction fraction (OEF), maps were calculated for detecting changes in tissue environment of brain diseases. As a result, the pHe value on glioblastoma or brain metastasis region was significantly lower than that on radiation necrosis (see Fig.3; P < 0.001). The OEF value on glioblastoma region recorded significantly lower values than radiation necrosis and lung metastasis (P < 0.001) while there was no significant difference amongst glioblastoma, breast metastasis, and lung metastasis (P > 0.05).
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