Abstract #0562

3D amplified MRI (aMRI) for visualizing pulsatile brain motion

Itamar Terem*¹, Leo Dang*², Allen Champagne³, Javid Abderezaei ⁴, Zainab Almadan ², Anna-Maria Lydon ⁵, Mehmet Kurt^4,6, Miriam Scadeng^2,7,8, and Samantha J Holdsworth^2,8

¹Department of Electrical Engineering & Department of Structural Biology, Stanford University, Stanford, CA, United States, ²Department of Anatomy and Medical Imaging & Centre for Brain Research, University of Auckland, Auckland, New Zealand, ³Centre for Neuroscience Studies, Queen’s University, Kingston, ON, Canada, ⁴Department of Mechanical Engineering, Stevens Institute of Technology, Hoboken, NJ, United States, ⁵Centre for Advanced MRI, University of Auckland, Auckland, New Zealand, ⁶Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁷Department of Radiology, University of California, San Diego, CA, United States, ⁸Mātai Medical Research Institute, Gisborne-Tairāwhiti, New Zealand

Amplified Magnetic Resonance Imaging (aMRI) has been introduced as a new brain motion detection and visualization method. Originally employed to amplify pulsatile brain motion in 2D, aMRI has shown to be promising for differentiating abnormal from normal pulsatile brain motion in obstructive brain disorders. Here, we further improve aMRI with the introduction of a combined 3D aMRI acquisition and post-processing tool, with subsequent image processing with optical flow and strain mapping. The 3D aMRI tool is then tested on both multi-slice and volumetric data and its ability to capture 3D brain motion is analyzed.

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