Abstract #0584

Quantitative Ferumoxytol Dynamic Contrast Enhanced (DCE) MRI Evaluation of the Placenta after Zika Virus Infection in the Rhesus Macaque

Daniel Seiter¹, Kai D. Ludwig¹, Sydney Nguyen^2,3,4, Megan E Murphy^2,3,4, Kathleen M Antony^2,3,4, Ruiming Chen¹, Terry K Morgan⁵, Ante Zhu^6,7, Archana Dhyani⁸, Sean B Fain^1,6,7, Kevin M Johnson^1,7, Thaddeus G. Golos^2,3,4, and Oliver Wieben^1,7

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, United States, ³Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States, ⁴Obstetrics & Gynecology, University of Wisconsin-Madison, Madison, WI, United States, ⁵Pathology, Oregon Health & Science University, Portland, OR, United States, ⁶Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁷Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁸Computer Science, University of Wisconsin-Madison, Madison, WI, United States

Proper placental development is crucial to fetal health. Here we report preliminary results characterizing the effects of Zika virus on the placenta of the rhesus macaque using dynamic contrast enhanced (DCE) MRI scans. DCE data were processed to identify individual cotyledons, their volume, and blood flow at three time points during gestation and were compared with pathological findings from term placenta dissection. Analysis shows a statistically significant decrease in cotyledon volume with pathology, measurable as early as 64 days gestation.

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