Abstract #0628

mGLUR5 and GABAA Receptor’s Association with fMRI BOLD Signals in the Default Mode Network as Assessed via Simultaneously recorded PET/MR data

Ravichandran Rajkumar^1,2,3, Claudia Régio Brambilla^1,2,3, Christine Wyss^1,4, Shukti Ramkiran^1,2, Linda Orth^1,2, Joshua Lewis Bierbrier^1,5, Elena Rota Kops¹, Jürgen Scheins¹, Bernd Neumaier⁶, Johannes Ermert⁶, Hans Herzog¹, Karl Joseph Langen^1,3,7, Christoph Lerche¹, N. Jon Shah^1,3,8,9, and Irene Neuner^1,2,3

¹Institute of Neuroscience and Medicine 4 (INM-4), Forschungszentrum Jülich, Jülich, Germany, ²Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, ³JARA – BRAIN – Translational Medicine, Aachen, Germany, ⁴Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zürich, Switzerland, ⁵Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, ⁶Institute of Neuroscience and Medicine 5 (INM-5), Forschungszentrum Jülich, Jülich, Germany, ⁷Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, ⁸Institute of Neuroscience and Medicine 11 (INM-11), Forschungszentrum Jülich, Jülich, Germany, ⁹Department of Neurology, RWTH Aachen University, Aachen, Germany

fMRI-BOLD signals reflect the synaptic activity and glucose energy metabolism in the brain. This study investigated the association between excitatory (mGLUR5), inhibitory (GABA_A) neuroreceptors, and glucose metabolism using PET imaging with resting-state fMRI for the first time. The significantly higher mGLUR5 and GABA_A neuroreceptor availability and glucose metabolism within the DMN and its correlations show a possible association between increased energy requirements and neuronal activity in the DMN. Further correlations with fMRI measurements show that higher energy demand is utilised for higher functional connectivity, and consecutively higher connectivity within the DMN is more strongly associated with inhibitory receptors.

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