Oral squamous cell carcinoma (OSCC) has maintained poor prognosis due to its aggressive nature and lack of targetable biomarkers for early and accurate detection. We have developed a targeted MRI contrast agent specific to extradomain-B fibronectin (EDB-FN), an extracellular matrix protein closely associated with tumor aggressiveness. Immunohistochemical analysis revealed strong EDB-FN expression in OSCC with minimal expression in normal tongue tissue. MR molecular imaging with our targeted contrast agent demonstrated the ability for differential contrast enhancement of aggressive OSCC tumors, underscoring the potential for using EDB-FN as a targetable biomarker for precision molecular imaging of OSCC.
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