Cerebrospinal fluid (CSF) flow dynamics are relevant parameters in the diagnosis of neurological diseases and can be accessed by three-dimensional time-resolved phase-contrast MRI (4D flow MRI). However, these measurements are accompanied by long scan times making acquisition acceleration necessary to accomplish clinical feasibility. The aim of this study was to evaluate the feasibility of compressed sensing (CS) acceleration in 4D flow MRI of the CSF. CS factors 4 to 10 were compared against the conventional SENSE in 16 healthy subjects. Preliminary results show feasibility of CS factor 6 with comparable image and velocity data quality.