Diffusion gradients are known to yield MR hardware vibrations, which may lead to signal loss in DW measurements especially at high b-values. The present work proposes to mitigate vibration-induced signal loss by introducing a vibration matching gradient (VMG). Laser interferometry was employed to measure the displacements induced by high b-value DW MR spectroscopy, focusing on the quantification of lipids ADC. The measured displacement patterns during the two diffusion gradients were more similar when using the VMG. The application of VMG showed an improvement in lipid ADC quantification in both a water-fat phantom and a volunteer’s tibial bone marrow.
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