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Abstract #0699

Metabolic Imaging of a Porcine Model of Acute Lung Injury Using Hyperpolarized [1-13C] Pyruvate MRI

Mehrdad Pourfathi1, Hooman Hamedani1,2, Yi Xin1,2, Michael Rosalino1, Stephen J Kadlecek1, Ian Duncan1, Maurizio Cereda1,3, Sarmad Siddiqui1, Harrilla Profka1, Luis Loza1, Faraz Amzajerdian 1,2, Tahmina Achekzai1, Kai Ruppert1, Federico Sertic1,4, Ryan Baron1, Jon Snow1, Yiwen Qian1,2, Gabriel Unger1, Shampa Chatterjee5, and Rahim R. Rizi1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 3Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, 4Surgery, University of Pennsylvania, Philadelphia, PA, United States, 5Physiology, University of Pennsylvania, Philadelphia, PA, United States

Transpulmonary lactate gradient is strongly correlated with the severity of lung injury and inflammation in ARDS patients. Hyperpolarized [1-13C] pyruvate MRI allows us to quantitatively study altered pyruvate-to-lactate conversion in cancerous and inflamed tissues. We sought to demonstrate the translational potential of this technology for pulmonary metabolic imaging in humans. We performed [1-13C] pyruvate lung MRI in an experimental model of aspiration pneumonitis in pigs, demonstrating this technology’s capacity to detect changes in pulmonary anaerobic metabolism after inflammatory injury in larger species.

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