Intra-axonal axial diffusivity could be interesting biomarker of disease, yet it is often assumed constant across the white matter. Furthermore, when intra-axonal diffusivity is estimated, few models account for fibre orientation dispersion which (when not explicitly modelled) will greatly affect the estimates of axial diffusion. Here we combine the stick model of intra-axonal diffusion with a simple model of fibre dispersion to simultaneously estimate intra-axonal axial diffusivity and fibre dispersion on a voxel-wise basis in high b-value data. Our results demonstrate considerable variability in the intra-axonal axial diffusivity across the white matter.
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