Abstract #0740

Whole-brain mapping of cortical architectonic features with high-resolution MAP-MRI

Alexandru V. Avram^1,2, Kadharbatcha Saleem^1,2, Frank Q Ye³, Cecil Yen⁴, Michal E Komlosh^1,2, and Peter J Basser¹

¹NICHD, National Institutes of Health, Bethesda, MD, United States, ²The Henry Jackson Foundation, Bethesda, MD, United States, ³NIMH, National Institutes of Health, Bethesda, MD, United States, ⁴NINDS, National Institutes of Health, Bethesda, MD, United States

We apply high-resolution mean apparent propagator (MAP)-MRI to quantify cortical architectonic features in a fixed rhesus macaque brain. Cortical depth profiles of MAP-derived parameters, such as the propagator anisotropy (PA), correlate well with histological stains in corresponding brain regions, and may be used to automatically detect boundaries between cortical areas with distinct cyto- and myeloarchitectonic organization. Mapping cortical architectonic features non-invasively could provide a new radiological tool for diagnosis of developmental and neurodegenerative disorders and improve our understanding of how the human brain is organized and connected.

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