We investigated the variation of ADC values obtained at diffusion times that are clinically available for differentiation of human breast tumors. The ADC values in both malignant and benign breast tumors decreased with increased diffusion time, and a larger change in ADC values was found in malignant tumors. The significant association found between ADC change and Ki-67 expression might indicate the potential of diffusion time-dependent ADC values as a tool to differentiate these prognostic biomarkers and assess tumor heterogeneity without the need for contrast agents.
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