Tractometry is a widely used tool to investigate microstructural properties that reflect differences in white matter tracts. It consists in averaging tissue features (obtained from any voxel-wise map) along streamlines recovered with diffusion tractography. To overcome the bias introduced by the average, we propose a new method to deconvolve on each individual tract the actual value measured by the microstructural map. For the first time we were able to assess the bundle-specific myelin content by combining tractography with two myelin-sensitive sequences and we obtained good agreement with previously reported values on the cortex.
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