Abstract #0862

Grading bladder urothelial carcinoma using a non-Gaussian fractional order calculus diffusion model

Cui Feng^1,2, Yanchun Wang¹, Guangyu Dan^2,3, Zheng Zhong^2,3, M. Muge Karaman^2,3, Daoyu Hu¹, and Xiaohong Joe Zhou^2,3,4,5

¹Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ²Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, ³Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ⁴Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States, ⁵Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL, United States

Diffusion-weighted imaging based on apparent diffusion coefficient (ADC) has been used for bladder urothelial carcinoma grading. However, a considerable overlap between the low- and high-grade bladder urothelial carcinoma has hindered its clinical acceptance. We employed high b-value diffusion imaging with a non-Gaussian fractional-order calculus (FROC) diffusion model for grading bladder urothelial carcinoma. Significant differences were observed in the FROC parameters D, β and μ, between the low- and high-grade urothelial carcinoma. The combination of the FROC parameters provided substantially better performance than ADC. These findings indicate a promising role of FROC parameters for characterizing bladder urothelial carcinoma and beyond.

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