Abstract #0877

Fast Simultaneous T1, T2 and T2* Mapping at High Spatial Resolution using 3D Echo-planar Time-resolved Imaging (3D-EPTI)

Fuyixue Wang^1,2, Zijing Dong^1,3, Timothy G. Reese¹, Lawrence L. Wald^1,2, and Kawin Setsompop^1,2

¹A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, ³3Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States

An efficient quantitative mapping sequence based on 3D Echo-Planar Time-resolved Imaging (3D-EPTI) is proposed. The acquisition contains inversion recovery gradient echo readouts follow by GRASE-like readouts to provide sensitivity to T₁, T₂ and T₂*. Fast k-TI-TE coverage is achieved by fusing highly-accelerated spatiotemporal CAIPI sampling with golden-angle radial-blade Cartesian under-sampling, where the reconstruction is performed using the subspace model. We demonstrate the high-efficiency of the proposed technique by obtaining multi-contrast images and quantitative maps at 1-mm isotropic resolution whole-brain in 3 minutes.

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