Abstract #0915

Neurocognitive and psychiatric features among primary Sjögren’s syndrome patients: from clinical outcomes to brain MRI

Radjiv Goulabchand^1,2,3, Veronica Ravano^4,5,6, Mário João Fartaria^4,5,6, Ricardo Corredor-Jerez^4,5,6, Elodie Castille^1,3, Sophie Navucet⁷, Alexandre Maria^1,2,8, Alain Le Quellec^1,2, Emmanuelle Le Bars^9,10,11, Audrey Gabelle^2,7,12, Philippe Guilpain^1,3,8, Nicolas Menjot de Champfleur^9,10, and Bénédicte Maréchal^4,5,6

¹Département de médecine interne et maladies multi-organiques, Hôpital Saint Eloi, CHRU Montpellier, Montpellier, France, ²Médecine interne, CHU de Nîmes, Nîmes, France, ³Faculté de médecine, Université de Montpellier, Montpellier, France, ⁴Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁵Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁶LTS 5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁷Centre Mémoire de Ressources et de Recherche, Hôpital Gui De Chauliac, CHRU Montpellier, Montpellier, France, ⁸IRMB, INSERM, CHU Montpellier, Montpellier, France, ⁹Département d’imagerie médicale, Hôpital Gui de Chauliac, CHRU Montpellier, Montpellier, France, ¹⁰Institut d'Imagerie Fonctionnelle Humaine (I2FH), Hôpital Gui de Chauliac, Centre Hospitalier Régional Universitaire de Montpellier, Montpellier, France, ¹¹Laboratoire Charles Coulomb, CNRS UMR 5221, Université de Montpellier, Montpellier, France, ¹²Laboratoire de Biochimie-Protéomique Clinique - IRMB - CCBHM - Inserm U1183, CHU Montpellier, Hôpital St-Eloi - Université Montpellier, Montpellier, France

To date, neuropsychiatric profiles in Sjögren’s syndrome patients are not explained by the immunological profile or clinical symptoms. Consequently, there is a lack of biomarkers potentially characterizing such profiles for this rare autoimmune disease. Our goal was to investigate the potential of MRI-based features to objectively explain fatigue, depression and cognitive complaints in twenty-nine patients with primary Sjögren’s syndrome. Specifically, we explored features from automated brain morphometry and brain lesion segmentation as potential imaging biomarkers. Z-score differences in certain brain structures (thalamus, corpus callosum, ventricles, and insula) were found, suggesting an association between MRI-based biomarkers and patient’s neuropsychiatric profiles.

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