Abstract #0940

Significance of Perivascular Spaces in Acute Ischemic Stroke and its Predictions of Epileptogenesis

Nian Yu^1,2,3, Benjamin Sinclair^4,5, Lina Maria Garcia Posada⁶, Ben Chen⁴, Qing Di¹, Xingjian Lin¹, Qingling Huang⁷, Scott Kolbe⁴, Patrick Kwan^2,4,5,8, and Meng Law^4,6

¹Department of Neurology, The Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China, ²Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia, ³Department of Radiology, The Nanjing Brain Hospital Affiliated to Nanjing Medical University, Melbourne, China, ⁴Department of Neuroscience, Monash University, Melbourne, Australia, ⁵Department of Neurology, Alfred Hospital, Melbourne, Australia, ⁶Department of Radiology, Alfred Hospital, Melbourne, Australia, ⁷Department of Radiology, The Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China, ⁸Department of Medicine, University of Melbourne, Melbourne, Australia

Around 10% of patients with stroke go on to develop epilepsy, however, imaging biomarkers for post-stroke epilepsy (PSE) are lacking. Perivascular spaces (PVS) are small interstitial fluid filled spaces lining the blood vessels which have a role in waste clearance in the brain. They have been found to be abnormal in epilepsy, and here we investigate whether they could serve as an early predictor of PSE. We found that the overall number and scores of enlarged PVSs were not associated with PSE, but the inter-hemispheric asymmetry was an independently associated biomarker.

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