Abstract #0963

Acquisition of a reference Connectom diffusion MRI dataset: In vivo whole-brain diffusion MRI at 760 µm isotropic averaged over 18 hours

Fuyixue Wang^1,2, Zijing Dong^1,3, Qiyuan Tian¹, Congyu Liao¹, Qiuyun Fan¹, W. Scott Hoge⁴, Chanon Ngamsombat¹, Boris Keil⁵, Jonathan R. Polimeni^1,2, Lawrence L. Wald^1,2, Susie Y. Huang^1,2, and Kawin Setsompop^1,2

¹A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, ³3Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, ⁴Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, ⁵Department of Life Science Engineering, Institute of Medical Physics and Radiation Protection, Giessen, Germany

We present a whole brain in vivo diffusion MRI dataset acquired at 760um isotropic resolution and sampled at 1260 q-space points across 9 two-hour sessions. The creation of this benchmark in vivo diffusion MRI dataset is possible through use of the Connectom scanner, custom-built 64-channel phased-array coil, gSlider acquisition, dual-polarity GRAPPA reconstruction, reverse phase encoding for distortion mitigation, and personalized motion-robust stabilizer. The data will enhance our understanding of gray and white matter structure with fine detail revealed at sub-mm resolution and serve as a reference dataset for new modeling and processing algorithms.

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