Abstract #1059

Treatment efficacy of asymptomatic carotid artery stenosis patients evaluated by clinically applicable hemodynamic MRI and cognitive testing

Stephan Kaczmarz^1,2, Jens Göttler^1,2,3, Jan Petr⁴, Nico Sollmann¹, Lena Schmitzer¹, Andreas Hock⁵, Mikkel Bo Hansen⁶, Kim Mouridsen⁶, Claus Zimmer¹, Fahmeed Hyder², and Christine Preibisch^1,7

¹School of Medicine, Department of Neuroradiology, Technical University of Munich, Munich, Germany, ²MRRC, Yale University, New Haven, CT, United States, ³School of Medicine, Department of Radiology, Technical University of Munich, Munich, Germany, ⁴Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ⁵Philips Healthcare, Hamburg, Germany, ⁶Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁷School of Medicine, Clinic of Neurology, Technical University of Munich, Munich, Germany

Hemodynamic MRI is highly promising to improve treatment decisions in asymptomatic internal carotid artery stenosis (ICAS). However, treatment efficacy evaluations require clinically applicable techniques, such as dynamic susceptibility contrast (DSC) and resting-state BOLD-based evaluations of amplitude of low-frequency fluctuations (ALFF). We present data from 16 asymptomatic ICAS patients before and after treatment and 17 age-matched healthy controls measuring cerebral blood volume (CBV) and capillary transit-time heterogeneity (CTH) by DSC and ALFF with additional cognitive testing. We hypothesized recovery of hemodynamic impairments after revascularization. Our results confirmed this hypothesis for all parameters. Interestingly, at the same time cognitive function remained impaired.

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