Abstract #1067

Association of conventional vascular risk factors with asymptomatic and symptomatic intracranial atherosclerosis

Yongjun Han^1,2, Runhua Zhang³, DanDan Yang^1,2, Hualu Han², Huiyu Qiao², Dongye Li⁴, Shuo Chen², Gaifen Liu³, and Xihai Zhao²

¹Center for Brain Disorders Research, Capital Medical University and Beijing Institute of Brain Disorders, Beijing, China, ²Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China, ³Department of Neurology, Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases, Beijing, China, ⁴Department of radiology, Sun Yat-sen Memorial hospital, Sun Yat-sen University, Beijing, China

This study investigated the association of vascular risk factors with asymptomatic and symptomatic ICAD using MR vascular wall imaging. Compared with controls, there was a positive association between hypertension and asymptomatic ICAD; and a positive association of hypertension, LDL, and diabetes and an inverse association of HDL with symptomatic ICAD (all p<0.05). Compared to asymptomatic ICAD, there was an inverse association between hyperlipidemia and symptomatic ICAD (p<0.001). We found that hypertension was a risk factor of asymptomatic ICAD and hypertension, diabetes and higher LDL were risk factors for symptomatic ICAD, whereas HDL was inversely associated with symptomatic ICAD.

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