Abstract #1171

Ex vivo MRI template of the human cervical cord at 80μm isotropic resolution

Charley Gros¹, Abdullah Asiri^2,3, Benjamin De Leener⁴, Charles Watson⁵, Gary Cowin⁶, Marc Ruitenberg⁷, Nyoman Kurniawan², and Julien Cohen-Adad^1,8

¹NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ²Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ³Radiology department, College of applied medical sciences, Najran University, Najran, Saudi Arabia, ⁴Department of Computer and Software Engineering, Polytechnique Montreal, Montreal, QC, Canada, ⁵Faculty of Health Sciences, Curtin University of Technology, Perth, Australia, ⁶National Imaging Facility, Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ⁷School of Biomedical Sciences, The University of Queensland, Brisbane, Australia, ⁸Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada

Spinal cord MRI templates allow reproducible and large scale atlas-based studies. However, current templates may have suboptimal resolutions (~0.5mm isotropic) to analyse high resolution data acquired at ultra-high field (e.g. 7T scanners). We generated a 3D human cervical cord template at 80µm isotropic resolution, from 13 ex vivo specimens, with a reference based on spinal levels. Further, the template was registered to the existing in vivo PAM50 template. Results showed consistency with histological studies in terms of grey matter morphology, and template generation achieved high accuracy (mean distance error: 0.10±0.01mm). The template and related scripts will be made publicly available.

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