Oxidative stress plays a significant role in the pathogenesis of heart disease. Nitroxide free radicals have been used as redox-sensitive MRI contrast agents where oxidative stress is correlated to the nitroxide-enhanced signal decay rate. We developed a two-compartment exchange and reduction model (2CXRM) to quantify both myocardial nitroxide exchange and reduction and hypothesized that dynamic nitroxide-enhanced MRI can comprehensively assess nitroxide kinetics in mouse models of angiotensin II infusion (ANGII) and myocardial infarction (MI). The 2CXRM detected elevated reduction rates in ANGII and post-MI mice indicative of oxidative stress and reduced nitroxide delivery, consistent with microvascular damage, in post-MI mice.
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