In-vivo laminar CBF fMRI was performed by high resolution (0.5×0.5×1.5 mm3) inner-volume GRASE with optimized pCASL labeling at 7T. Activation of finger-tapping task (5 blocks, TA=10 min) was reliably detected in all 4 subjects. Both rest/FT CBF peaks in the middle layers, which corresponds to highest capillary density in cortex layer IV. FT evoked CBF increase shows one peak in middle layer, and a second shoulder in deep layer. The capability to provide quantitative CBF measurements at both baseline and task activation with high specificity to neuronal activities is a unique strength of ASL fMRI compared to other fMRI techniques.