Delta relaxation enhanced magnetic resonance (dreMR) is a field-shifting quantitative molecular imaging method using activatable MR probes. The dreMR method may be used to produce images with signal proportional to concentration of contrast agent and eliminate signal due to unbound agent. In this work we outline a novel design method for dreMR coils, using an inner layer of windings determined by the boundary element method (BEM). This new design method produces a strong, highly homogeneous field shift which, when coupled with a 0.5T MRI system and activatable MR probes, can reliably image on a larger volume than previous designs.
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