Evaluating tissue properties prior-to or during therapy, such as locating cancerous and necrotic cells, or characterizing response to radiation or ablation, is conventionally performed by tissue excision, followed by pathologic examination. An alternative is diagnosing tissue in-situ without removing it, as performed using Optical-Coherence-Tomography or Intra-Vascular-UltraSound. We aim to perform tissue definition in soft-tissues not accessed through body-orifices or blood-vessels by combining; (1) Steerable tissue-puncture, (2) MR-Tracking-motion-localization, and (3) imaging along the punctured-holes' walls. Utilization requires rapid high-CNR multiple-contrast MRI. A deflectable virtual-biopsy “gun” for diagnosing cervical-cancer radiation-therapy response was developed. It imaged ~15mm surrounding punctured-holes created for brachytherapy seed-delivery.