Abstract #1345

Assessing the origin of human alpha oscillations using laminar layer 7T fMRI-EEG

Daniel C. Marsh¹, Rodika Sokoliuk², Kevin M. Aquino^1,3, Daisie O. Pakenham¹, Ross Wilson², Rosa Sanchez Panchuelo¹, Matthew J Brookes¹, Simon Hanslmayr², Stephen D. Mayhew², Susan T Francis¹, and Karen J Mullinger^1,2

¹Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, United Kingdom, ³Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia

EEG alpha (8-13Hz) oscillations occur throughout the cortex but the generating mechanisms are poorly understood. Opinion is divided between alpha being driven by bottom-up, top-down or both these processes. Here we use simultaneous 7T-fMRI-EEG during periods of eyes open/closed to assess the generator of alpha by determining the strongest BOLD-alpha negative layer correlations. We show the feasibility of using high spatial resolution 7T-fMRI with EEG to understand the origin of oscillations. Preliminary analysis shows BOLD-alpha correlations peak in middle layers of V1 (but not in V2/V3) providing suggestion that the alpha oscillations investigated are driven by bottom-up processing.

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