Abstract #1362

Locus Coeruleus derived norepinephrine alters intrinsic functional connectivity at the Default-Mode Network

Li-Ming Hsu^1,2,3,4, Esteban Oyarzabal^1,3,4, Manasmita Das^1,3,4, Tzu-Hao Harry Chao^1,3,4, Sheng Song^1,3,4, Yu-Wei Chen⁵, Dinggang Shen², Sungho Lee^1,3,4, Patricia Jensen⁶, and Yen-Yu Ian Shih^1,3,4

¹Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Biomedical Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁴Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁵Developmental Neurobiology, NIEHS/NIH, RDU, NC, United States, ⁶Developmental Neurobiology, NIH/NIEHS, RDU, NC, United States

Norepinephrine (NE) is suspected to rapidly modulate strength and structure of intrinsic functional connectivity (FC). We used chemogenetic fMRI to selectively isolate the role of NE Locus Coeruleus (LC) neurons, compared to NE A1/A2/A4 neurons, on FC modulation. Among 19 parcellated FC modules, NE-LC neurons significantly enhanced ReHo, ALFF and DC within the anterior Default-Mode, Motor and Somatosensory modules and enhanced FC strength within and between Default-Mode modules. Dynamic FC analysis found Default-Mode differences were attributed to two co-activation patterns (CAPs) associated with Default-Mode suppression that explains the ability of NE to focus wandering minds into sensory attention.

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