Abstract #1422

Monitoring the treatment effect of Tecfidera on MS lesion susceptibility with quantitative susceptibility mapping

Xianfu Luo^1,2, Elizabeth Sweeney³, Ulrike W. Kaunzner⁴, Weiyuan Huang¹, David Pitt⁵, Yi Wang¹, Susan Gauthier⁴, and Thanh D. Nguyen¹

¹Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States, ²Department of Radiology, Northern Jiangsu People's Hospital, Yangzhou, China, ³Department of Healthcare Policy and Research, Weill Medical College of Cornell University, New York, NY, United States, ⁴Department of Neurology, Weill Medical College of Cornell University, New York, NY, United States, ⁵Yale University, New Haven, CT, United States

Quantitative susceptibility mapping (QSM) has emerged as a sensitive MRI tool for in vivo monitoring inflammation in MS brain. Low-grade inflammation in chronic active lesions have been shown to contain iron-enriched, activated microglia and macrophages on histopathology and have been linked to greater tissue damage. QSM can provide accurate in vivo quantification of iron-laden inflammatory cells. It might be used to assess treatment response.

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