Assessment of lesion evolution in Multiple Sclerosis (MS) is critical to monitor the disease progression but remains challenging in clinical practice. Inhomogeneous magnetization transfer (ihMT) is a promising technique that has demonstrated sensitivity to demyelination in preclinical and clinical studies. In this work, a 3D ihMT technique was integrated as part of a multiparametric MRI protocol and applied to active MS lesion follow up over a period of six months. Variations of ihMT ratio were compared to those of conventional magnetization transfer imaging and diffusion tensor imaging often used in clinical research to assess demyelination.
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