Characterization of age-related alterations in microstructure of locus coeruleus and its projections will aid in the development of new biomarkers and may provide insight in the development of novel interventions to arrest progression of Alzheimer's disease or Parkinson's disease. Imaging locus coeruleus with diffusion-weighted images is difficult due to its small stature (locus coeruleus is 1.5 mm in diameter and 15 mm long) and location in the brain stem. In this abstract, we utilize a high resolution diffusion-weighted protocol to examine age-related microstructural changes in locus coeruleus and examine its effect on age-related cognitive decline.
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