The dynamic longitudinal change of brain in progression of AD is still unknown. We analyzed the brain networks of AD patients at different stages. We found in global network properties, most differences only existed between healthy people and patients, and few were discovered between patients at different stages. However, nearly all subnetwork properties showed significant differences between patients at different stages. Moreover, we found two different functional evolving patterns of cortical networks in progression of AD, named ‘Temperature inversion’ and “Monotonous decline”, but not the same monotonous decline trend as the external functional assessment observed in disease progression.
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