Abstract #1477

The Evaluation of Cerebral Blood Flow Deficits in Parkinson’s Disease Dementia using ASL-MRI at 3T

Sena Tunçer¹, Dilek Betul Arslan¹, Tanya Ipek Deniz², Oznur Aslan ³, Ani Kiçik^4,5, Kardelen Eryürek^4,6, Emel Erdoğdu^4,7, Zerrin Yildirim⁸, Zeynep Tüfekcioglu⁸, Basar Bilgic⁸, Hasmet Hanagasi⁸, Hakan Gürvit⁸, Tamer Demiralp^4,9, and Esin Ozturk-Isık¹

¹Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, ²Department of Electrical and Electronic Engineering, Bogazici University, Istanbul, Turkey, ³Department of Biomedical Engineering, Namik Kemal University, Tekirdağ, Turkey, ⁴Neuroimaging Unit, Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, ⁵Department of Physiology, Faculty of Medicine, Demiroglu Bilim University, Istanbul, Turkey, ⁶Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, ⁷Department of Psychology, Faculty of Arts and Sciences, Isik University, Istanbul, Turkey, ⁸Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁹Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

This study aims to find cerebral blood flow (CBF) deficits in Parkinson’s disease dementia (PDD). ASL-MRI was utilized to obtain CBF values in PD patients with different stages of cognitive decline at 3T. The CBF values were compared using a whole brain voxel-based analysis. The findings of this study revealed that the PDD group had significant CBF reductions in posterior cerebral areas, mostly in visual cortices, but also in medial parietal areas, and cortical and thalamic components of dorsolateral prefrontal fronto-striatal circuit as compared to both PD group with mild cognitive impairment (PD-MCI) and the cognitively normal PD group (PD-CN).

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