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Abstract #1511

Susceptibility Map-Weighted Imaging and Neuromelanin-Sensitive MRI in Parkinson’s Disease

Septian Hartono1,2, Isabel Hui Min Chew3, Weiling Lee3, Amanda May Yeng Choo1, Celeste Yan Teng Chen1, Leon Qi Rong Ooi4, Lirong Yin3, Kuan Jin Lee5, Jongho Lee6, Ching-Yu Cheng7, Eng King Tan1,2, and Ling Ling Chan2,3
1National Neuroscience Institute, Singapore, Singapore, 2Duke-NUS Medical School, Singapore, Singapore, 3Singapore General Hospital, Singapore, Singapore, 4National University of Singapore, Singapore, Singapore, 5Singapore BioImaging Consortium, Singapore, Singapore, 6Seoul National University, Seoul, Republic of Korea, 7Singapore Eye Research Institute, Singapore, Singapore

Nigrosome-1 imaging and neuromelanin contrast have been identified as good radiological biomarkers of dopaminergic nigral degeneration in Parkinson's disease (PD) pathology. We evaluated the sensitivity of quantitative Susceptibility-Mapping Weighted Imaging (SMWI) derived from Quantitative Susceptibility Mapping (QSM) and neuromelanin sensitive (NMS) imaging in differentiating a case control cohort of PD patients. Region-of-interest analysis of the substantia nigra on both QSM/SMWI and NMS offered excellent differentiation of PD and healthy controls. However, QSM/SMWI offered more robust disease classification compared to NMS and might be preferred for use in the clinical setting.

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