Abstract #1513

Default mode network connectivity differences in levodopa responsive subtypes of Parkinson’s disease patients with freezing of gait.

Karthik R Sreenivasan¹, Xiaowei Zhuang¹, Jason Longhurst¹, Zhengshi Yang¹, Dietmar Cordes¹, Aaron Ritter¹, Jessica Caldwell¹, Jeffrey L Cummings¹, Zoltan Mari¹, Irene Litvan², Brent Bluett³, and Virendra Mishra¹

¹Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, ²University of California San Diego, La Jolla, CA, United States, ³Stanford University, Palo Alto, CA, United States

Dopaminergic deficiency can cause altered deactivation of the default mode network (DMN) connectivity, which subsequently impacts executive task performance resulting in freezing of gait (FOG). While the majority of Parkinson’s disease (PD) patients with FOG (PD-FOG) are responsive to levodopa, about 36% of PD patients are levodopa-resistant. Our results show increased DMN connectivity in levodopa-resistant PD-FOG group. Furthermore, we found that altered network connectivity in the levodopa-resistant group was correlated differently with neuropsychological measures. To the best of our knowledge this is the first study to investigate the functional connectivity differences in levodopa-resistant subtypes in PD-FOG.

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