Abstract #1516

Investigating Iron deposition in the Substantia Nigra of Early Parkinson’s Disease and Idiopathic REM Sleep Behavior Disorder using QSM and R2*

Rahul Gaurav^1,2, Romain Valabregue¹, Nadya Pyatigorskaya¹, Emma Biondetti¹, Graziella Mangone³, Claire Ewenczyk⁴, Matthew Hutchison⁵, Isabelle Arnulf⁶, Jean-Christophe Corvol⁴, Marie Vidailhet⁴, Mathieu D. Santin¹, and Stephane Lehericy¹

¹CENIR - Center for Neuroimaging Research, ICM - Brain and Spine Institute, Paris, France, ²Move'IT - Movement Investigations and Therapeutics, ICM - Brain and Spine Institute, Paris, France, ³Clinical Investigation Center (CIC-9503), INSERM - French National Institute of Medical Research and Health, Paris, France, ⁴Department of Neurology, Pitie-Salpetriere Hospital, Paris, France, ⁵Biogen Inc., Cambridge, MA, United States, ⁶Sleep Disorders Unit, Pitie-Salpetriere Hospital, Paris, France

Parkinson’s disease (PD) and idiopathic rapid eye movement sleep behavior disorder (iRBD) demonstrate neurodegenerative changes in the substantia nigra (SN) associated with an increase in iron deposition in PD patients. We aimed to quantify iron overload in the SN in early stage PD and iRBD patients using QSM-based and neuromelanin (NM)-based automated segmentation for QSM and R2* maps. We observed an increase in iron deposition in both early PD and iRBD patients with respect to healthy volunteers (HV).

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