Abstract #1526

Investigation of subcortical brain structures in patients with Parkinson's disease using a quantitative susceptibility mapping atlas

Boliang Yu¹, Ling Li², Xueling Liu², Naying He³, Hongjiang Wei⁴, Chuantao Zuo², Fuhua Yan³, and Yuyao Zhang¹

¹School of Information Science and Technology, ShanghaiTech University, Shanghai, China, ²PET Center, Huashan Hospital, Fudan University, Shanghai, China, ³Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, ⁴Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

A limited number of atlases have been constructed using quantitative susceptibility mapping (QSM) images from subjects with Parkinson’s disease (PD), and given disease-specific subcortical structures. In this work, we generated three standard-space templates i.e. the hybrid, QSM and T1w atlas, which kept good image quality to observe brain white, gray matter, and deep-brain nuclei. Based on the atlases, we achieved the manual annotation of a few brain subcortical structures, e.g. globus pallidus, substantia nigra, subthalamic nucleus and thalamus. The results gave the position and shape of subcortical nuclei which could be meaningful for the research and surgical treatment of PD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here