Abstract #1538

Relationship between Free Water and Neuroinflammation/Neurodegeneration Markers in HIV Before and After Combination Antiretroviral Therapy

Md Nasir Uddin¹, Abrar Faiyaz², Yuchuan Zhuang², Madalina Tivarus^3,4, Jianhui Zhong^4,5, Maxime Descoteaux⁶, and Giovanni Schifitto^4,7

¹Department of Neurology, University of Rochester, Rochester, NY, United States, ²Electrical & Computer Engineering, University of Rochester, Rochester, NY, United States, ³Radiology, University of Rochester, Rochester, NY, United States, ⁴Imaging Sciences, University of Rochester, Rochester, NY, United States, ⁵Physics, University of Rochester, Rochester, NY, United States, ⁶Computer Science, University of Sherbrooke, Sherbrooke, QC, Canada, ⁷Neurology, University of Rochester, Rochester, NY, United States

Free water (FW) index, a measure of extracellular non-flowing water in the brain parenchyma, can be sensitive to neuroinflammation. We examine the relationship between the FW index and putative markers of neuroinflammation in cART-naïve participants before and after 12 weeks of the treatment. We found that FW index correlated with neuroinflammation markers in HIV+ participants for some GM and WM structures at baseline while this correlation diminished after 12 weeks of cART treatment in some WM structures for NfL.

This abstract and the presentation materials are available to members only; a login is required.

Join Here