Na Lu1,2, Shuhua Li3, Chunmei Li1, Pu-Yeh Wu4, Wen Su3, Haibo Chen3, Piu Chan3, and Min Chen1,2
1Department of Radiology, Beijing Hospital, National Center of Gerontology, Beijing, China, 2Graduate School of Peking Union Medical College, Beijing, China, 3Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing, China, 4GE Healthcare, MR Research China, Beijing, China
Multiple system atrophy (MSA) is in great need of
diagnosis in its early stage. Our study aims to evaluate the feasibility of
using amide proton transfer (APT) imaging in detection of multiple system
atrophy (MSA) at 3.0 Tesla. We found that APT MTRasym values were significantly
higher in MSA patients than in normal controls at red nucleus, substantia
nigra, thalamus and putamen. We also found that APT MTRasym values were
significantly higher in probable MSA than in possible MSA patients at red
nucleus, caudate and putamen. Hence, CEST may be valuable in diagnosing and
predicting the progression of MSA.
