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Abstract #1548

Grey matter volume alterations in trigeminal neuralgia: A systematic review and meta-analysis of voxel-based morphometry studies

Yu Tang1, Maohua Wang2, Ting Zheng1, Fengying Yuan1, Fugang Han1, and Guangxiang Chen1
1Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China, 2Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China

In recent decades, a growing number of structural neuroimaging studies of grey matter (GM) in trigeminal neuralgia (TN) have reported inconsistent alterations. We carried out a systematic review and meta-analysis to identify consistent and replicable GM volume abnormalities in TN patients. Our findings provide a thorough profile of GM volume alterations in TN patients and constitute robust evidence that aberrant GM volumes in the brain regions regulating and moderating sensory-motor and affective processing may play an important role in the pathophysiology of TN.

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