HIV-infected individuals are at increased risk of developing white matter hyperintensities (WMHs), which can lead to increased iron deposition in deep gray matter structures. In this abstract, we evaluate three region of interest (ROI) brain iron metrics and introduce a novel population-based whole-brain iron metric, the expected iron coefficient (EIC), derived from quantitative susceptibility mapping (QSM) in the context of HIV and mild WMH burden. While the ROI metrics did not show any significant differences between cohorts, the EIC was able to detect iron related differences in a cohort with WMH burden, due to increased statistical power.
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