Myalgic Encephalomyelitis (ME)/Chronic fatigue syndrome (CFS) patients suffer from a variety of physical and neurological complaints indicating the central nervous system plays a role in CFS pathophysiology. Studies based on genetic, immune system, psychiatric, and brain volume abnormalities and white matter hyperintensities have been investigated to identify the pathomechanism of this disease. However, assessment of myelination in brain regions between ME/CFS patients and healthy controls has not been investigated. In this study, we showed elevated myelination in white matter regions and grey matter regions in ME/CFS patients relative to normal controls.
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