Abstract #1564

Proximal Nerve Quantitative MRI in Charcot-Marie-Tooth (CMT) Diseases

Yongsheng Chen¹, E. Mark Haacke², Yang Xuan², Melody Hackett¹, Sadaf Saba³, Bo Hu¹, Daniel Moiseev¹, and Jun Li^1,3,4,5

¹Department of Neurology, Wayne State University, Detroit, MI, United States, ²Department of Radiology, Wayne State University, Detroit, MI, United States, ³Center for Molecular Medicine & Genetics, Wayne State University, Detroit, MI, United States, ⁴Department of Biochemistry, Microbiology and Immunology, Wayne State University, Detroit, MI, United States, ⁵John D. Dingell VA Medical Center, Detroit, MI, United States

To test the hypothesis that quantitative MRI (qMRI) detects proximal nerve dysmyelination and axonal degeneration in Charcot-Marie-Tooth (CMT) diseases. Nine qMRI indices were collected, including whole muscle mean fat fraction (wmmFF), nerve fascicular cross-sectional area (fCSA), magnetization transfer ratio (MTR), T1, proton density (PD), R2, R2*, mean diffusivity (MD) and fractional anisotropy (FA). Compared to controls, patients with CMT had significantly elevated fCSA, T1, PD, T2* and MD for both divisions of sciatic nerves and wmmFF, elevated T2 for the tibial division but not the peroneal division, and decreased MTR for both divisions of sciatic nerves.

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