Abstract #1579

Lesion distribution and substrate in Type 1 Myotonic Dystrophy: comparison with Multiple Sclerosis

Sara Leddy¹, Laura Serra², Davide Esposito³, Camilla Vizzotto⁴, Gabriella Silvestri⁵, Antonio Petrucci⁶, Giovanni Meola⁷, Mara Cercignani^2,8, and Marco Bozzali^2,8

¹Brighton and Sussex University Hospitals Trust, Brighton, United Kingdom, ²Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy, ³Department of Vascular and Endovascular Surgery, University of Florence, Florence, Italy, ⁴University of, Rome, Italy, ⁵Department of Geriatrics, Orthopedics and Neuroscience, Catholic University of Sacred Heart Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ⁶UOC Neurologia e Neurofisiopatologia, AO San Camillo Forlanini, Rome, Italy, ⁷Department of Neurorehabilitation Sciences, Casa di Cura Policlinico, Milan, Italy, ⁸Department of Neuroscience, University of Sussex, Brighton, United Kingdom

This study compares the lesion distribution and substrate (by means of quantitative MRI) between patients with type 1 Myotonic Dystrophy (DM1) and patients with Multiple Sclerosis (MS). The main differences in anatomical distribution are the prevalence of anterior temporal lobe lesions in the former group, in the absence of cerebellum and brainstem lesions. MRI markers of myelination were not different between the normal appearing white matter of DM1 and healthy controls. By contrast they were reduced in lesions, but larger than in MS lesions.

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