High risk plaque is the is the predominant risk factor of stroke. Accurate diagnosis and intervention could prevent patients from cerebrovascular events. Axial, circumferential and 3D wall shear stress calculated by 4D flow MRI were utilized to explore the difference between high risk plaque patients and low risk plaque patients. The results demonstrated the WSS were all significant higher in high risk plaque group. Our results may provide crucial clues to therapeutic interventions.