Systemic Lupus Erythematosus (SLE) often presents with neuropsychiatric (NP) symptoms. These symptoms can be directly associated with SLE (NP-SLE) or not (non-NP-SLE). We investigated whether white matter hyperintensity (WMH) features (such as type, volume and shape) may contribute to the diagnosis of NP-SLE. Patients with NP-SLE more often had deep WMH (DWMH) compared to patients with non-NP-SLE. There were no significant differences in WMH volume and shape features between NP-SLE patients compared to non-NP-SLE patients. In conclusion, NP-SLE patients more often had DWMH compared to non-NP-SLE patients and this may help in the diagnostic process of NP-SLE.