End-stage renal disease (ESRD) has become risk factor for vascular disease, stroke and cognitive dysfunction, and the white matter lesions may be associated with these adverse outcomes. Silent white matter alterations may occur in the earlier stages, whereas conventional MR imaging may not be found, This study aim to detect subtle white matter alterations in patients with ESRD through diffusion tensor imaging (DTI). DTI can reflect early occult white matter damage in ESRD patients.
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